A group of six young vacationers who, looking to go off the beaten path, hire an "extreme" tour guide. Ignoring warnings, he takes them into the city of Pripyat, the former home to the workers of the Chernobyl nuclear reactor, but a deserted town since the disaster more than 25 years ago.

Like most teenagers, Peter is trying to figure out who he is and how he got to be the person he is today. Peter is also finding his way with his first high school crush, Gwen Stacy, and together, they struggle with love, commitment, and secrets. As Peter discovers a mysterious briefcase that belonged to his father, he begins a quest to understand his parents’ disappearance – leading him directly to Oscorp and the lab of Dr Curt Connors, his father’s former partner. As Spider-Man is set on a collision course with Connors’ alter-ego, The Lizard, Peter will make life-altering choices to use his powers and shape his destiny to become a hero.